Mesaconic acid (Standard)

Overview

Mesaconic acid (Standard) is the analytical standard of Mesaconic acid. This product is intended for research and analytical applications. Mesaconic acid (Citronic acid; Methylfumaric acid) is an orally active anti-inflammatory and antioxidant agent. Mesaconic acid reduces the level of NF-κB in colon tissues, downregulates the expression of Keap1 and Bax , upregulates the expression of Nrf2 and Bcl2 , and decreases the expression of Caspase-1 . Mesaconic acid reduces the levels of NLRP3 , ASC and Casp-1 in colon, liver and kidney tissues. Mesaconic acid reduces pro-inflammatory cytokine levels, increases the level of the anti-inflammatory cytokine IL-10 , elevates NAD + levels, regulates oxidative stress markers and antioxidant enzyme levels, and upregulates intestinal barrier proteins in colon, liver and kidney tissues. Mesaconic acid increases the abundance of beneficial gut bacteria and reduces the abundance of harmful gut bacteria in rapidly aging mice, and exhibits anti-aging properties. Mesaconic acid acts as a flame retardant and serves as a competitive inhibitor of fumarate reduction. Mesaconic acid can be used in the research of aging-related inflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Antioxidant Agent | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Cathepsin | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Endogenous Metabolite | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-78036R
• CAS No.: 498-24-8
• Molecular Formula: C5H6O4
• Molecular Weight: 130.10
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source