Ac-Exatecan

Overview

Ac-Exatecan is acetylation-modified Exatecan ( HY-13631 ). Exatecan is a common toxin component in ADC preparation ( ADC cytotoxin ) and an inhibitor of DNA topoisomerase I ( IC 50 = 2.2 μM). Exatecan has antitumor activity. Exatecan can be used as a payload for ADC. Exatecan is effective against P-glycoprotein mediated multi-drug resistant cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > ADC Payloads | Products > Signaling Pathways > Topoisomerase

Product Information

• Catalog No.: HY-79490
• CAS No.: 2922852-48-8
• Molecular Formula: C26H24FN3O5
• Molecular Weight: 477.48
• Purity: 99.02%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source