Lenalidomide

Overview

Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN) , and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3 , by the CRBN-CRL4 ubiquitin ligase . Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

Application

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Product Information

• Catalog No.: HY-A0003
• CAS No.: 191732-72-6
• Molecular Formula: C13H13N3O3
• Molecular Weight: 259.26
• Purity: 99.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution
• Availability: In-stock

Source

Original product source