Doxylamine-d 5

Overview

Doxylamine -d 5 is deuterium labeled Doxylamine ( HY-A0069A ). Doxylamine is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine is orally active, possessing analgesic and hypnotic activities. Doxylamine enhances the activities of CYP2B , CYP2A , CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450 , cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine can be used for the research of nausea, allergy, insomnia.

Application

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Product Information

• Catalog No.: HY-A0069AS
• CAS No.: 1173020-59-1
• Molecular Formula: C17H17D5N2O
• Molecular Weight: 275.40
• Purity: 99.9%
• Storage: Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source