Cilazaprilat

Overview

Cilazapril at is an inhibitor of angiotensin-converting enzyme (ACE; IC 50 =0.7 nM for the rat enzyme) and an active metabolite of Cilazapril ( HY-A0043 ). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Angiotensin-converting Enzyme (ACE)

Product Information

• Catalog No.: HY-A0113
• CAS No.: 90139-06-3
• Molecular Formula: C20H27N3O5
• Molecular Weight: 389.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source