Moexiprilat

Overview

Moexipril at is an inhibitor of angiotensin-converting enzyme (ACE; IC 50 =2.1 nM) and an active metabolite of the prodrug Moexipril ( HY-117281 ). It is formed from moexipril in vivo by side chain ester hydrolysis. Moexipril at (10 nM) prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts. It reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide, a marker of hypertension, in ovariectomized mice when administered at a dose of 50 mg/kg per day.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Angiotensin-converting Enzyme (ACE)

Product Information

• Catalog No.: HY-A0114
• CAS No.: 103775-14-0
• Molecular Formula: C25H30N2O7
• Molecular Weight: 470.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source