Halofantrine hydrochloride

Overview

Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine hydrochloride inhibits the Cap1 -dependent oxidative stress response of Candida albicans , suppresses ROS responses, and enhances the antifungal ( Fungal ) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.

Application

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Product Information

• Catalog No.: HY-A0148A
• CAS No.: 36167-63-2
• Molecular Formula: C26H31Cl3F3NO
• Molecular Weight: 536.88
• Purity: 99.9%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 3 mg/mL (5.59 mM); Clear solution
• Availability: In-stock

Source

Original product source