Dexbrompheniramine

Overview

Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin ( HY-10448 )-induced responses. The combination of Dexbrompheniramine with Cimetidine ( HY-14289 ) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms.

Application

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Product Information

• Catalog No.: HY-A0191
• CAS No.: 132-21-8
• Molecular Formula: C16H19BrN2
• Molecular Weight: 319.24
• Purity: 99.93%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution
• Availability: In-stock

Source

Original product source