Pamidronic acid

Overview

Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin , and is applicable for research on osteoporosis and osteosarcoma.

Application

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Product Information

• Catalog No.: HY-B0012
• CAS No.: 40391-99-9
• Molecular Formula: C3H11NO7P2
• Molecular Weight: 235.07
• Purity: 99.05%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 2 mg/mL (8.51 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source