Ciluprevir

Overview

Ciluprevir (BILN 2061; BILN 2061ZW) is an orally active macrocyclic peptide inhibitor of hepatitis C virus ( HCV ) NS3 protease, with an IC 50 of 3 nM. Ciluprevir has Kᵢ values of 0.66 nM and 0.30 nM against genotypes 1b and 1a, respectively. Ciluprevir inhibits HCV RNA replication with an EC 50 of 1.2 nM, and its EC50 values against genotypes 1b and 1a are 3 nM and 4 nM, respectively. Ciluprevir shows no significant inhibition against human leukocyte elastase and hepatic cathepsin B . Ciluprevir can be used for genotype 1 HCV infection .

Application

Products | Products > Disease Areas > Hepatitis C Virus Infection | Products > Disease Areas > Infection | Products > Disease Areas > Hepatitis Virus Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > HCV | Products > Signaling Pathways > HCV Protease | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-10242
• CAS No.: 300832-84-2
• Molecular Formula: C40H50N6O8S
• Molecular Weight: 774.93
• Purity: 98.08%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source