Furosemide is a potent and orally active inhibitor of Na + /K + /2Cl - ( NKCC ) cotransporter , NKCC1 and NKCC2. Furosemide is also a GABA A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
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