Clemastine

Overview

Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor ( H1 histamine receptor ) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors ( mAChR ), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and p yroptosis , exerting anti- apoptotic and neuroprotective effects, and suppressing inflammation.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Glaucoma | Products > Disease Areas > Cardiomyopathy | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > mAChR | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > p62 | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > IKK | Products > Signaling Pathways > Histamine Receptor

Product Information

• Catalog No.: HY-B0298
• CAS No.: 15686-51-8
• Molecular Formula: C21H26ClNO
• Molecular Weight: 343.89
• Purity: 99.26%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.27 mM); Clear solution
• Availability: In-stock

Source

Original product source