Dyclonine hydrochloride

Overview

Dyclonine hydrochloride (Dyclocaine hydrochloride) is an orally active, blood-brain barrier-permeable piperidine phenylacetone small molecule commonly used as a local anesthetic. Dyclonine hydrochloride acts as a highly selective allosteric antagonist of TRPV3 ; it also reversibly inhibits G9a , ALDH2 and ALDH3A1 , non-competitively blocks AChE . Dyclonine hydrochloride activates the Nrf2/ARE pathway, relieves the epigenetic silencing of FXN , blocks Aβ42 aggregation, and promotes remyelination and reparative polarization of microglia. Dyclonine hydrochloride alleviates pruritus via TRPV3 inhibition; it is used in studies of neurodegenerative disease models based on its AChE inhibitory, antioxidant and remyelinating effects; it sensitizes drug-resistant tumors through ALDH inhibition, and combined use with protease inhibitors induces more tumor cell apoptosis ; it inhibits Candida albicans in vitro. Dyclonine hydrochloride can be used for research on multiple diseases including neurodegenerative diseases, cancer and pruritic dermatitis.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Fungal Infection | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Skin Inflammation | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > TRP Channel | Products > Signaling Pathways > Aldehyde Dehydrogenase (ALDH)

Product Information

• Catalog No.: HY-B0364A
• CAS No.: 536-43-6
• Molecular Formula: C18H28ClNO2
• Molecular Weight: 325.87
• Purity: 99.12%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (7.67 mM); Clear solution
• Availability: In-stock

Source

Original product source