Dyclonine hydrochloride (Standard)

Overview

Dyclonine hydrochloride (Standard) (Dyclocaine hydrochloride (Standard)) is the analytical standard of Dyclonine hydrochloride ( HY-B0364A ). This product is intended for research and analytical applications. Dyclonine hydrochloride (Dyclocaine hydrochloride) is an orally active, blood-brain barrier-permeable piperidine phenylacetone small molecule commonly used as a local anesthetic. Dyclonine hydrochloride acts as a highly selective allosteric antagonist of TRPV3 ; it also reversibly inhibits G9a , ALDH2 and ALDH3A1 , non-competitively blocks AChE . Dyclonine hydrochloride activates the Nrf2/ARE pathway, relieves the epigenetic silencing of FXN , blocks Aβ42 aggregation, and promotes remyelination and reparative polarization of microglia. Dyclonine hydrochloride alleviates pruritus via TRPV3 inhibition; it is used in studies of neurodegenerative disease models based on its AChE inhibitory, antioxidant and remyelinating effects; it sensitizes drug-resistant tumors through ALDH inhibition, and combined use with protease inhibitors induces more tumor cell apoptosis ; it inhibits Candida albicans in vitro. Dyclonine hydrochloride can be used for research on multiple diseases including neurodegenerative diseases, cancer and pruritic dermatitis.

Application

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Product Information

• Catalog No.: HY-B0364AR
• CAS No.: 536-43-6
• Molecular Formula: C₁₈H₂₈ClNO₂
• Molecular Weight: 325.87
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source