Famotidine (GMP)

Overview

Famotidine GMP (MK-208 GMP) is Famotidine ( HY-B0377 ) produced in GMP guideline. Famotidine is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3 -mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9 , improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase , exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lower Respiratory Inflammation | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Gastric Disease | Products > Disease Areas > Peptic Ulcer Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Pneumonia | Products > Disease Areas > Gastric Ulcer | Products > Disease Areas > Liver Injury | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-B0377G
• CAS No.: 76824-35-6
• Molecular Formula: C8H15N7O2S3
• Molecular Weight: 337.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source