Almotriptan malate

Overview

Almotriptan malate (PNU180638) is an orally active, highly selective agonist of the 5-HT 1B/1D receptor ( 5-HT 1B/1D receptor ), with EC 50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan malate shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan malate induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan malate can be used in research related to migraine.

Application

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Product Information

• Catalog No.: HY-B0383
• CAS No.: 181183-52-8
• Molecular Formula: C21H31N3O7S
• Molecular Weight: 469.55
• Purity: 99.53%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.32 mM); Clear solution
• Availability: In-stock

Source

Original product source