Almotriptan

Overview

Almotriptan (PNU180638 free base) is an orally active, highly selective agonist of the 5-HT 1B/1D receptor ( 5-HT 1B/1D receptor ), with EC 50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan can be used in research related to migraine.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Depression | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-B0383A
• CAS No.: 154323-57-6
• Molecular Formula: C17H25N3O2S
• Molecular Weight: 335.46
• Purity: 99.18%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution
• Availability: In-stock

Source

Original product source