Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a K i value of 6 nM and an EC 90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease . Narlaprevir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 2.3 μM.
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