Articaine

Overview

Articaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4 , hNav1.7 , and rNav1.8 ), with an IC 50 of 15.8 μM for open-state Na + channels, and IC 50 of 40.6 μM and 378 μM for inactivated and resting-state Na + channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na + influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-B0516A
• CAS No.: 23964-58-1
• Molecular Formula: C13H20N2O3S
• Molecular Weight: 284.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source