Amitriptyline-d 6 hydrochloride

Overview

Amitriptyline-d 6 hydrochloride is the deuterium labeled Amitriptyline hydrochloride ( HY-B0527A ). Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT ( K i = 3.45 nM) and NET ( K i = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine ( 5-HT ) and norepinephrine ( NE ) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis ). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with K i = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) ( K i = 11-24 nM), H1 receptors ( K i = 0.5-1.1 nM), adrenergic α1 receptors ( K i = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel ( IC 50 = 4.78 μM) and it has cardiotoxicity.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Serotonin Transporter | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > mAChR | Products > Signaling Pathways > Adrenergic Receptor | Products > Signaling Pathways > Trk Receptor | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Dopamine Transporter | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Isotope-Labeled Compounds

Product Information

• Catalog No.: HY-B0527AS
• CAS No.: 203645-63-0
• Molecular Formula: C20H18D6ClN
• Molecular Weight: 319.90
• Purity: 99.93%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source