Doxapram hydrochloride hydrate (Standard)

Overview

Doxapram hydrochloride hydrate (Standard) is the analytical standard of Doxapram hydrochloride hydrate ( HY-B0551A ). This product is intended for research and analytical applications. Doxapram hydrochloride hydrate is a respiratory stimulant. Doxapram hydrochloride hydrate increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram hydrochloride hydrate inhibits TASK-1 , TASK-3 , TASK-1/TASK-3 heterodimeric channel function with EC 50 s of 410 nM, 37 μM, 9 μM, respectively. Doxapram hydrochloride hydrate inhibits the Ca²⁺-activated potassium current ( IC 50 ≈ 13 μM) and Ca²⁺-independent potassium current ( IC 50 ≈ 20 μM) in type I cells of the carotid body. Doxapram hydrochloride hydrate significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram hydrochloride hydrate can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity.

Application

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Product Information

• Catalog No.: HY-B0551AR
• CAS No.: 7081-53-0
• Molecular Formula: C24H33ClN2O3
• Molecular Weight: 432.98
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source