Methyclothiazide is an orally active antihypertensive agent and a diuretic agent . Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine ( HY-13715 ). Methyclothiazide is against voltage-dependent Ca-channel ( VDCC ) activity in vitro.
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