Cyclosporin A

Overview

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC 50 of 5 nM. Cyclosporin A is a molecular glue , binds to cyclophilin and calcineurin , leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion.

Application

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Product Information

• Catalog No.: HY-B0579
• CAS No.: 59865-13-3
• Molecular Formula: C62H111N11O12
• Molecular Weight: 1202.61
• Purity: 99.90%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 2.62 mg/mL (2.18 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source