Tetrabenazine Racemate

Overview

Tetrabenazine (Ro 1-9569) Racemate is a brain-penetrant and orally active VMAT2 -selective ligand with human VMAT2 K i 100 nM. Tetrabenazine Racemate binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine Racemate weakly blocks dopamine D2 receptors , and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine Racemate can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Monoamine Transporter | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-B0590A
• CAS No.: 718635-93-9
• Molecular Formula: C19H27NO3
• Molecular Weight: 317.42
• Purity: 99.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (7.88 mM); Clear solution
• Availability: In-stock

Source

Original product source