Desvenlafaxine-d 10 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine ( HY-B0196 ), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC 50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter.
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