Metformin-d 6

Overview

Metformin -d 6 (1,1-Dimethylbiguanide-d 6 ) is a deuterated labeled Metformin ( HY-B0627 ). Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy -related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

Application

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Product Information

• Catalog No.: HY-B0627S
• CAS No.: 1185512-92-8
• Molecular Formula: C4H5D6N5
• Molecular Weight: 135.20
• Purity: 98.16%
• Storage: Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source