Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin mesylate inhibits DNA gyrase with IC 50 values of 0.88 μg/mL ( E. coli ) and 1.9 μg/mL ( P. aeruginosa ). Pazufloxacin mesylate exhibits broad-spectrum antimicrobial activity, with MIC 90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin mesylate is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia.
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