Hydrastine

Overview

Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH) , inhibiting dopamine biosynthesis (IC 50 =20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 ( IC 50 =6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage.

Application

Products | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Tyrosine Hydroxylase | Products > Signaling Pathways > OAT | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-B0927
• CAS No.: 118-08-1
• Molecular Formula: C21H21NO6
• Molecular Weight: 383.39
• Purity: 99.57%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution
• Availability: In-stock

Source

Original product source