Fendiline hydrochloride

Overview

Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker ( IC 50 of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras . Fendiline hydrochloride inhibits K-Ras plasma membrane localization ( IC 50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras . Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10).

Application

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Product Information

• Catalog No.: HY-B0984
• CAS No.: 13636-18-5
• Molecular Formula: C23H26ClN
• Molecular Weight: 351.91
• Purity: 99.78%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (5.91 mM); Clear solution
• Availability: In-stock

Source

Original product source