Fendiline

Overview

Fendiline, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker ( IC 50 of 17 µM). Fendiline is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras . Fendiline inhibits K-Ras plasma membrane localization ( IC 50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras . Fendiline is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10).

Application

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Product Information

• Catalog No.: HY-B0984A
• CAS No.: 13042-18-7
• Molecular Formula: C23H25N
• Molecular Weight: 315.45
• Purity: 99.41%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution
• Availability: In-stock

Source

Original product source