SB228357 is a selective, potent and orall active 5-HT 2C/2B receptor antagonist with pK i values of 6.9, 8.0 and 9.0 for 5-HT 2A , 5-HT 2B and 5-HT 2C , respectively. SB228357 has antidepressant/anxiolytic effects.
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