Nomifensine-d 3 ((±)-Nomifensine-d 3 ) maleate is the deuterium labeled Nomifensine maleate ( HY-B1110A ). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC 50 values of 6.6 nM, 48 nM and 830 nM, and K i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research.
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