Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID) , with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC 50 s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases ( caspase-1 , 3, 4, 5, 9) inhibitor.
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