PSB36

Overview

PSB36 is a highly selective A 1 adenosine receptor antagonist, with a K i of 0.12 nM and a K d of 0.7 nM. Systemic administration of PSB36 reduces formalin- and Carrageenan ( HY-125474 )-induced edema in mice and decreases pain-related behaviors, with no local paw activity. PSB36 prolongs the APD 90 of rat and human atria, produces a frequency-dependent prolongation of rat atrial ERP, increases the diastolic threshold of rat atria, and shortens the duration of atrial fibrillation episodes. PSB36 can be used in research related to inflammatory pain, inflammatory hyperalgesia, edema and atrial fibrillation.

Application

Products | Products > Disease Areas > Pain | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Atrial Fibrillation | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Heart Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Adenosine Receptor

Product Information

• Catalog No.: HY-103175
• CAS No.: 524944-72-7
• Molecular Formula: C21H30N4O3
• Molecular Weight: 386.49
• Purity: 99.13%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution
• Availability: In-stock

Source

Original product source