Tetramisole

Overview

Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC 50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Infection | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > PKA

Product Information

• Catalog No.: HY-B1194A
• CAS No.: 5036-02-2
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.29
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source