Protoporphyrin IX

Overview

Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) ( HY-W000450 ) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma.

Application

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Product Information

• Catalog No.: HY-B1247
• CAS No.: 553-12-8
• Molecular Formula: C34H34N4O4
• Molecular Weight: 562.66
• Purity: 98.0%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source