NKH477

Overview

NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Adenylate Cyclase

Product Information

• Catalog No.: HY-103193
• CAS No.: 138605-00-2
• Molecular Formula: C27H44ClNO8
• Molecular Weight: 546.09
• Purity: 99.86%
• Storage: -20°C, protect from light, stored under nitrogen * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 5 mg/mL (9.16 mM); Clear solution
• Availability: In-stock

Source

Original product source