Quinpirole

Overview

Quinpirole (LY 171555; (-)-LY 141865) is a D2/D3 dopamine receptor agonist and a CaV1.3 calcium channel modulator. Quinpirole normalizes dendritic spine density in dopamine-depleted striatum, upregulates the protein expression of BCL2 and GluR2 , downregulates the protein expression of BAX , and delays the onset of seizures. Quinpirole enhances learning and memory, inhibits neuronal apoptosis ( apoptosis ), and induces anxiety-like, stereotyped, and compulsive behaviors. Quinpirole disrupts prepulse inhibition in rhesus monkeys, enhances the activity of paraventricular thalamic neurons to promote recovery from Isoflurane anesthesia, and alters the composition of the gut microbiota in rats. Quinpirole can be used in research related to dyskinesia, pain, epilepsy, and neurological disorders including anxiety disorder, obsessive-compulsive disorder, and schizophrenia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Schizophrenia | Products > Disease Areas > Epilepsy | Products > Disease Areas > Anxiety or Fear-Related Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > iGluR

Product Information

• Catalog No.: HY-B1752
• CAS No.: 80373-22-4
• Molecular Formula: C13H21N3
• Molecular Weight: 219.33
• Purity: 98.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (11.40 mM); Clear solution
• Availability: In-stock

Source

Original product source