Thifluzamide

Overview

Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II . Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis , Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Fungal Infection | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Environmental Pollutants | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Fungal

Product Information

• Catalog No.: HY-B2004
• CAS No.: 130000-40-7
• Molecular Formula: C13H6Br2F6N2O2S
• Molecular Weight: 528.06
• Purity: 98.36%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source