NBI 35965 methanesulfonate

Overview

NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K i value of 4 nM and a pK i value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC 50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > CRFR

Product Information

• Catalog No.: HY-103378
• CAS No.: 603151-83-3
• Molecular Formula: C22H26Cl2N4O3S
• Molecular Weight: 497.44
• Purity: 96.43%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source