NCX 466

Overview

NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-β ( TGF-β ) and oxidative stress markers (such as thiobarbituric acid reactive substances ( TBARS ) and 8-hydroxy-2'-deoxyguanosine ( 8-OHdG )), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase ( MPO ) activity, thereby preventing bleomycin ( HY-108345 )-induced pulmonary fibrosis in mice.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > COX | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > Glutathione Peroxidase

Product Information

• Catalog No.: HY-103388
• CAS No.: 1262956-64-8
• Molecular Formula: C20H24N2O9
• Molecular Weight: 436.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source