Trovafloxacin mesylate

Overview

Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive , Gram-negative and anaerobic organisms . Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC 50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

Application

Products | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Antibiotic

Product Information

• Catalog No.: HY-103399
• CAS No.: 147059-75-4
• Molecular Formula: C21H19F3N4O6S
• Molecular Weight: 512.46
• Purity: 99.76%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.08 mg/mL (4.06 mM); Clear solution
• Availability: In-stock

Source

Original product source