NF279

Overview

NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC 50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4 , CCR5 , CXCR3 , and CXCR7 -mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > HIV Infection | Products > Disease Areas > Sexually Transmitted Disease | Products > Disease Areas > HIV-1 Infection | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Infection | Products > Signaling Pathways > P2X Receptor | Products > Signaling Pathways > HIV | Products > Signaling Pathways > NTPDase | Products > Signaling Pathways > CXCR

Product Information

• Catalog No.: HY-D0976
• CAS No.: 202983-32-2
• Molecular Formula: C49H30N6Na6O23S6
• Molecular Weight: 1401.12
• Purity: 98.5%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source