5(6)-Carboxy-2',7'-dichlorofluorescein diacetate

Overview

5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species ( ROS ) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC 4 for MRP2 binding sites and inhibits MRP2 -mediated LTC 4 transport (Ex/Em = 496/525 nm).

Application

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Product Information

• Catalog No.: HY-D1078
• CAS No.: 127770-45-0
• Molecular Formula: C25H14Cl2O9
• Molecular Weight: 529.28
• Purity: 97.5%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source