HKI-357

Overview

HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC 50 s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

Application

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Product Information

• Catalog No.: HY-103443
• CAS No.: 848133-17-5
• Molecular Formula: C31H29ClFN5O3
• Molecular Weight: 574.05
• Purity: 98.10%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.36 mM); Clear solution
• Availability: In-stock

Source

Original product source