RhoNox-4

Overview

RhoNox-4 is a Fe 2+ -selective fluorescence-activatable probe and an inhibitor of ferroptosis . RhoNox-4 shows no obvious cytotoxicity even at concentrations up to 50 μM. RhoNox-4 can selectively oxidize labile Fe 2+ to Fe 3+ , depleting the iron pool required for lipid peroxidation and ferroptosis . RhoNox-4 inhibits ferroptosis induced by ferroptosis inducers; its activity depends on localization to the endoplasmic reticulum/Golgi apparatus, and it does not affect apoptosis or necrosis. RhoNox-4 can be used for imaging labile Fe 2+ in living cells, and also enables high-throughput screening of labile iron homeostasis regulators based on 96-well plates. RhoNox-4 allows visualization of cytoplasmic Fe 2+ levels in root tips of *Arabidopsis* (Ex/Em = 530-560/573-647 nm).

Application

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Product Information

• Catalog No.: HY-D3116
• CAS No.: 2711762-70-6
• Molecular Formula: C38H44N4O8
• Molecular Weight: 684.78
• Purity: 98.65%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source