S-Acetonyl-CoA (Acetonyl-coenzyme A) is a non-reactive structural analog of acetyl-CoA that acts as a competitive inhibitor against multiple target enzymes . S-Acetonyl-CoA lacks the characteristic thioester group of acetyl-CoA, retaining only a thioether structure. S-Acetonyl-CoA competes with acetyl-CoA for binding to citrate synthase , phosphate transacetylase , carnitine acetyltransferase , and N-myristoyltransferase 1 . S-Acetonyl-CoA serves as a reagent for investigating acetyl-CoA-dependent physiological processes.
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