N-Desmethyl imatinib (Standard)

Overview

N‑Desmethyl imatinib (Standard) is the analytical standard of N‑Desmethyl imatinib (Norimatinib) ( HY-G0017R ). This product is intended for research and analytical applications. N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib ( HY-15463 ), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein . N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection . N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Others | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > P-glycoprotein | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-G0017R
• CAS No.: 404844-02-6
• Molecular Formula: C28H29N7O
• Molecular Weight: 479.59
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source