2'-Acetylacteoside

Overview

2'-Acetylacteoside (2'-AA) is a natural compound with oral activity and blood-brain barrier permeability. 2'-Acetylacteosideexhibits MAO‑B inhibitory activity ( IC 50 = 17.71 μM, K i = 13.81 μM). 2'-Acetylacteoside downregulates the expression of RANK , TRAF6 , NF‑κB , NFATc1 and IKKβ , disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt . 2'-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2'-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinson's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Ischemic Stroke | Products > Disease Areas > Osteoporosis | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Monoamine Oxidase | Products > Signaling Pathways > RANKL/RANK | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > IKK

Product Information

• Catalog No.: HY-N0026
• CAS No.: 94492-24-7
• Molecular Formula: C31H38O16
• Molecular Weight: 666.62
• Purity: 99.73%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (3.75 mM); Clear solution
• Availability: In-stock

Source

Original product source