AMN082 free base

Overview

AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding ( EC 50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7 . AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Depression | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR

Product Information

• Catalog No.: HY-103565A
• CAS No.: 83027-13-8
• Molecular Formula: C28H28N2
• Molecular Weight: 392.54
• Purity: 98.37%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 1.25 mg/mL (3.18 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source